Association of air pollution and use of glyceryl trinitrate against angina pectoris: a population-based case-crossover study
Identifieur interne : 000476 ( Main/Exploration ); précédent : 000475; suivant : 000477Association of air pollution and use of glyceryl trinitrate against angina pectoris: a population-based case-crossover study
Auteurs : Ragnhildur Gudrun Finnbjornsdottir [Islande] ; Helga Zoëga [Islande] ; Orn Olafsson [Islande] ; Throstur Thorsteinsson [Islande] ; Vilhjalmur Rafnsson [Islande]Source :
- Environmental Health [ 1476-069X ] ; 2013.
Abstract
Ambient air pollution has been associated with increased cardiovascular morbidity and mortality. In Reykjavik, Iceland, air pollutant concentrations exceed official health limits several times every year. The aim was to study the association of concentrations of NO2, O3, PM10, and H2S in the Reykjavik capital area with the dispensing of anti-angina pectoris medication,
Data on daily dispensing of
For every 10 μg/m3 increase of NO2 and O3 3-day mean concentrations, the odds ratio (OR) for daily dispensing of
These findings suggest that NO2 and O3 ambient air concentrations may adversely affect cardiovascular health, as measured by the dispensing of
Url:
DOI: 10.1186/1476-069X-12-38
PubMed: 23631813
PubMed Central: 3663824
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of air pollution and use of glyceryl trinitrate against angina pectoris: a population-based case-crossover study</title><author><name sortKey="Finnbjornsdottir, Ragnhildur Gudrun" sort="Finnbjornsdottir, Ragnhildur Gudrun" uniqKey="Finnbjornsdottir R" first="Ragnhildur Gudrun" last="Finnbjornsdottir">Ragnhildur Gudrun Finnbjornsdottir</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Zoega, Helga" sort="Zoega, Helga" uniqKey="Zoega H" first="Helga" last="Zoëga">Helga Zoëga</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Olafsson, Orn" sort="Olafsson, Orn" uniqKey="Olafsson O" first="Orn" last="Olafsson">Orn Olafsson</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsson, Throstur" sort="Thorsteinsson, Throstur" uniqKey="Thorsteinsson T" first="Throstur" last="Thorsteinsson">Throstur Thorsteinsson</name><affiliation wicri:level="1"><nlm:aff id="I2">Environment and Natural Resources, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Environment and Natural Resources, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Institute of Earth Sciences, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Institute of Earth Sciences, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Rafnsson, Vilhjalmur" sort="Rafnsson, Vilhjalmur" uniqKey="Rafnsson V" first="Vilhjalmur" last="Rafnsson">Vilhjalmur Rafnsson</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Preventive Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Preventive Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23631813</idno><idno type="pmc">3663824</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663824</idno><idno type="RBID">PMC:3663824</idno><idno type="doi">10.1186/1476-069X-12-38</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000161</idno><idno type="wicri:Area/Pmc/Curation">000159</idno><idno type="wicri:Area/Pmc/Checkpoint">000072</idno><idno type="wicri:Area/Ncbi/Merge">000355</idno><idno type="wicri:Area/Ncbi/Curation">000355</idno><idno type="wicri:Area/Ncbi/Checkpoint">000355</idno><idno type="wicri:Area/Main/Merge">000475</idno><idno type="wicri:Area/Main/Curation">000476</idno><idno type="wicri:Area/Main/Exploration">000476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of air pollution and use of glyceryl trinitrate against angina pectoris: a population-based case-crossover study</title><author><name sortKey="Finnbjornsdottir, Ragnhildur Gudrun" sort="Finnbjornsdottir, Ragnhildur Gudrun" uniqKey="Finnbjornsdottir R" first="Ragnhildur Gudrun" last="Finnbjornsdottir">Ragnhildur Gudrun Finnbjornsdottir</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Zoega, Helga" sort="Zoega, Helga" uniqKey="Zoega H" first="Helga" last="Zoëga">Helga Zoëga</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Olafsson, Orn" sort="Olafsson, Orn" uniqKey="Olafsson O" first="Orn" last="Olafsson">Orn Olafsson</name><affiliation wicri:level="1"><nlm:aff id="I1">Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsson, Throstur" sort="Thorsteinsson, Throstur" uniqKey="Thorsteinsson T" first="Throstur" last="Thorsteinsson">Throstur Thorsteinsson</name><affiliation wicri:level="1"><nlm:aff id="I2">Environment and Natural Resources, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Environment and Natural Resources, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Institute of Earth Sciences, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Institute of Earth Sciences, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Rafnsson, Vilhjalmur" sort="Rafnsson, Vilhjalmur" uniqKey="Rafnsson V" first="Vilhjalmur" last="Rafnsson">Vilhjalmur Rafnsson</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Preventive Medicine, University of Iceland, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Preventive Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental Health</title><idno type="eISSN">1476-069X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Ambient air pollution has been associated with increased cardiovascular morbidity and mortality. In Reykjavik, Iceland, air pollutant concentrations exceed official health limits several times every year. The aim was to study the association of concentrations of NO<sub>2</sub>, O<sub>3</sub>, PM<sub>10</sub>, and H<sub>2</sub>S in the Reykjavik capital area with the dispensing of anti-angina pectoris medication, <italic>glyceryl trinitrate</italic> to the inhabitants.</p></sec><sec><title>Methods</title><p>Data on daily dispensing of <italic>glyceryl trinitrate</italic>, were retrieved from the Icelandic Medicines Registry. Data on hourly concentrations of NO<sub>2</sub>, O<sub>3</sub>, PM<sub>10</sub>, and H<sub>2</sub>S were obtained from the Environment Agency of Iceland. A case-crossover design was used, based on the dispensing of <italic>glyceryl trinitrate</italic> to 5,246 individuals (≥18 years) between 2005 and 2009.</p></sec><sec><title>Results</title><p>For every 10 μg/m<sup>3</sup> increase of NO<sub>2</sub> and O<sub>3</sub> 3-day mean concentrations, the odds ratio (OR) for daily dispensing of <italic>glyceryl trinitrates</italic> was 1.136 (95% confidence intervals (CI) 1.069-1.207) and 1.094 (95% CI 1.029-1.163) at lag 0, and OR was 1.096 (95% CI 1.029-1.168) and 1.094 (95% CI 1.028-1.166) at lag 1, respectively.</p></sec><sec><title>Conclusions</title><p>These findings suggest that NO<sub>2</sub> and O<sub>3</sub> ambient air concentrations may adversely affect cardiovascular health, as measured by the dispensing of <italic>glyceryl trinitrates</italic> for angina pectoris. 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Boutouyrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hill, Ab" uniqKey="Hill A">AB Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhaskaran, K" uniqKey="Bhaskaran K">K Bhaskaran</name></author><author><name sortKey="Hajat, S" uniqKey="Hajat S">S Hajat</name></author><author><name sortKey="Armstrong, B" uniqKey="Armstrong B">B Armstrong</name></author><author><name sortKey="Haines, A" uniqKey="Haines A">A Haines</name></author><author><name sortKey="Herrett, E" uniqKey="Herrett E">E Herrett</name></author><author><name sortKey="Wilkinson, P" uniqKey="Wilkinson P">P Wilkinson</name></author><author><name sortKey="Smeeth, L" uniqKey="Smeeth L">L Smeeth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruidavets, Jb" uniqKey="Ruidavets J">JB Ruidavets</name></author><author><name sortKey="Cournot, M" uniqKey="Cournot M">M Cournot</name></author><author><name 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uniqKey="Bellander T">T Bellander</name></author><author><name sortKey="Berglind, N" uniqKey="Berglind N">N Berglind</name></author><author><name sortKey="D Ippoliti, D" uniqKey="D Ippoliti D">D D'Ippoliti</name></author><author><name sortKey="Elosua, R" uniqKey="Elosua R">R Elosua</name></author><author><name sortKey="Hormann, A" uniqKey="Hormann A">A Hormann</name></author><author><name sortKey="Kulmala, M" uniqKey="Kulmala M">M Kulmala</name></author><author><name sortKey="Lanki, T" uniqKey="Lanki T">T Lanki</name></author><author><name sortKey="Lowel, H" uniqKey="Lowel H">H Lowel</name></author><author><name sortKey="Pekkanen, J" uniqKey="Pekkanen J">J Pekkanen</name></author><author><name sortKey="Picciotto, S" uniqKey="Picciotto S">S Picciotto</name></author><author><name sortKey="Sunyer, J" uniqKey="Sunyer J">J Sunyer</name></author><author><name sortKey="Forastiere, F" uniqKey="Forastiere F">F Forastiere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poloniecki, J" uniqKey="Poloniecki J">J Poloniecki</name></author><author><name sortKey="Atkinson, R" uniqKey="Atkinson R">R Atkinson</name></author><author><name sortKey="De Leon, A" uniqKey="De Leon A">A de Leon</name></author><author><name sortKey="Anderson, H" uniqKey="Anderson H">H Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zanobetti, A" uniqKey="Zanobetti A">A Zanobetti</name></author><author><name sortKey="Schwartz, J" uniqKey="Schwartz J">J Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durand, M" uniqKey="Durand M">M Durand</name></author><author><name sortKey="Wilson, Jg" uniqKey="Wilson J">JG Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bates, Mn" uniqKey="Bates M">MN Bates</name></author><author><name sortKey="Garrett, N" uniqKey="Garrett N">N Garrett</name></author><author><name sortKey="Shoemack, P" uniqKey="Shoemack P">P Shoemack</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Islande</li></country></list><tree><country name="Islande"><noRegion><name sortKey="Finnbjornsdottir, Ragnhildur Gudrun" sort="Finnbjornsdottir, Ragnhildur Gudrun" uniqKey="Finnbjornsdottir R" first="Ragnhildur Gudrun" last="Finnbjornsdottir">Ragnhildur Gudrun Finnbjornsdottir</name></noRegion><name sortKey="Olafsson, Orn" sort="Olafsson, Orn" uniqKey="Olafsson O" first="Orn" last="Olafsson">Orn Olafsson</name><name sortKey="Rafnsson, Vilhjalmur" sort="Rafnsson, Vilhjalmur" uniqKey="Rafnsson V" first="Vilhjalmur" last="Rafnsson">Vilhjalmur Rafnsson</name><name sortKey="Thorsteinsson, Throstur" sort="Thorsteinsson, Throstur" uniqKey="Thorsteinsson T" first="Throstur" last="Thorsteinsson">Throstur Thorsteinsson</name><name sortKey="Thorsteinsson, Throstur" sort="Thorsteinsson, Throstur" uniqKey="Thorsteinsson T" first="Throstur" last="Thorsteinsson">Throstur Thorsteinsson</name><name sortKey="Zoega, Helga" sort="Zoega, Helga" uniqKey="Zoega H" first="Helga" last="Zoëga">Helga Zoëga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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